38+ Knockout Vs Transgenic Mice Images. Transgenic mice have significantly contributed to the understanding of molecular biology, genetics, immunology and cancer, besides creating animal models for several human genetic. The use of transgenic mice is one of the key approaches in elucidating gene function and regulation.
Frontiers Humanized Mouse Models Of Rheumatoid Arthritis For Studies On Immunopathogenesis And Preclinical Testing Of Cell Based Therapies Immunology from www.frontiersin.org Transgenic mice have wide applications in biomedical research. By contrast, transgenic models use random integration: Es cell transforma3on works well in mice only.
Now that we have the ability to map out the entire human genome and a genome library built, how do we know what the genes do?
The use of transgenic mice is one of the key approaches in elucidating gene function and regulation. Knocking out the activity of a gene provides valuable clues about what that gene normally does. Iwasato t, nomura r, ando r, ikeda t, tanaka m, itohara s. Mimic the action of antagonistic drugs.
